Mangiarotti taught at Istituto Superiore di Disegno Industriale of Venice (1963–64), University of Hawaii (1970), Ecole Politecnique Fédérale of Losanna (1974), University of Adelaide and South Australian Institute of Technology of Adelaide (1976), Architecture of Palermo (1982), Architecture of Florence (1983), and Architecture of Politecnico di Milano (1989–90).
The iconic Giogali Collection designed for Vistosi in 1967, featured handmade Murano crystal links that loop together to create endless stunning combinations, it has since become synonymous with Italian design as variations on this model were created soon after by various Italian designers & manufacturers.
In 1989 he founded Mangiarotti & Associates which was based in Tokyo. From 1986 to 1992 he was art director of Colle Cristalleria.
Mangiarotti’s designs expressed in the book "In nome dell’architettura" published in 1987 enlightened the essential characteristics of every object. Mangiarotti played an important role in plastic research in particular furthering the definition of the object’s form as a quality of the material. Mangiarotti design work is marked by many prizes in both design and architecture.